For more detailed information, examine the syllabus and course policies. For advice on how to succeed in this course, and in all other courses, take a peek at the lecture hints. Bloom's taxonomy of understanding will help you differentiate the increasing levels of insight of a topic.
In the table below, the second column includes the notes that I use in class. You can download or print a copy of the notes by clicking on the link in the topic column. The fourth column connects to readings from an earlier version of An Introduction to Genetic Analysis available at the National Center for Biotechnology Information (The links in the fourth column are not working, so copy the URL into your web browser address window to go to the correct website.) I suggest reading the text before coming to class.
Other important documentsSyllabus
Class Schedule
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| Dates (Approx.) | Topic | Chapter | Readings |
| 1/05 | Introduction Assessment of Previous Knowledge Inheritance CAT Cellular Reproduction CAT Molecular Biology CAT | Genetics
and the Organism Genes as determinants of the inherent properties of species Genetic variation Methodologies used in genetics Genes, the environment, and the organism |
http://www.ncbi.nlm.nih.gov/books/NBK21851/ http://www.ncbi.nlm.nih.gov/books/NBK22032/ http://www.ncbi.nlm.nih.gov/books/NBK22007/ http://www.ncbi.nlm.nih.gov/books/NBK22047/ http://www.ncbi.nlm.nih.gov/books/NBK21842/ |
| 1/12 | Classic Mendelian Genetics Pedigree Analysis | Patterns of
Inheritance Mendel's experiments Using genetic ratios Human genetics | http://www.ncbi.nlm.nih.gov/books/NBK22006/ http://www.ncbi.nlm.nih.gov/books/NBK22098/ http://www.ncbi.nlm.nih.gov/books/NBK21812/ http://www.ncbi.nlm.nih.gov/books/NBK21977/ |
| 1/19 | No Class - Martin Luther King Day | ||
| 1/26 | Chromosome Theory of Inheritance Mitosis Meiosis | Chromosomal Basis of Heredity Historical development of the chromosome theory Mendelian genetics in eukaryotic life cycles Sex chromosomes and sex-linked inheritance | http://www.ncbi.nlm.nih.gov/books/NBK21960/ http://www.ncbi.nlm.nih.gov/books/NBK22088/ http://www.ncbi.nlm.nih.gov/books/NBK21836/ http://www.ncbi.nlm.nih.gov/books/NBK22079/ |
| 2/02 | Linkage/Sex Linkage Pedigree Analysis (continued) | The
discovery of linkage Recombination Linkage symbolism Linkage of genes on the X chromosome Linkage maps Three-point testcross Interference Calculating recombinant frequencies from selfed dihybrids Examples of linkage maps Chi-square test for linkage Mapping with molecular markers Linkage mapping by recombination in humans Nature of crossing-over |
http://www.ncbi.nlm.nih.gov/books/NBK22076/ http://www.ncbi.nlm.nih.gov/books/NBK21889/ http://www.ncbi.nlm.nih.gov/books/NBK22023/ http://www.ncbi.nlm.nih.gov/books/NBK21909/ http://www.ncbi.nlm.nih.gov/books/NBK21827/ http://www.ncbi.nlm.nih.gov/books/NBK22073/ http://www.ncbi.nlm.nih.gov/books/NBK22051/ http://www.ncbi.nlm.nih.gov/books/NBK21906/ http://www.ncbi.nlm.nih.gov/books/NBK21784/ http://www.ncbi.nlm.nih.gov/books/NBK22084/ http://www.ncbi.nlm.nih.gov/books/NBK21962/ http://www.ncbi.nlm.nih.gov/books/NBK21799/ http://www.ncbi.nlm.nih.gov/books/NBK21900/ |
| 2/09 | DNA Structure and Replication | The Structure and
Replication of DNA DNA, The genetic material Structure of DNA Replication of DNA Mechanism of DNA replication |
http://www.ncbi.nlm.nih.gov/books/NBK21777/ http://www.ncbi.nlm.nih.gov/books/NBK22104/ http://www.ncbi.nlm.nih.gov/books/NBK21786/ http://www.ncbi.nlm.nih.gov/books/NBK21790/ http://www.ncbi.nlm.nih.gov/books/NBK21862/ |
| 2/16 | Transcription and Translation | Molecular Biology
of Gene Function Properties of RNA Transcription Transcription and RNA polymerase Eukaryotic RNA Translation Genetic Code Protein synthesis Universality of genetic information transfer Functional division of labor in the gene set | http://www.ncbi.nlm.nih.gov/books/NBK22039/ http://www.ncbi.nlm.nih.gov/books/NBK21880/ http://www.ncbi.nlm.nih.gov/books/NBK22071/ http://www.ncbi.nlm.nih.gov/books/NBK22085/ http://www.ncbi.nlm.nih.gov/books/NBK21853/ http://www.ncbi.nlm.nih.gov/books/NBK22109/ http://www.ncbi.nlm.nih.gov/books/NBK21950/ http://www.ncbi.nlm.nih.gov/books/NBK22022/ http://www.ncbi.nlm.nih.gov/books/NBK21915/ http://www.ncbi.nlm.nih.gov/books/NBK21761/ |
| 2/23 | Metabolic Pathways Mutants and Complementation | A
diagnostic test for alleles How genes work Gene-protein relations Genetic fine structure Mutational sites Complementation |
http://www.ncbi.nlm.nih.gov/books/NBK21921/ http://www.ncbi.nlm.nih.gov/books/NBK22044/ http://www.ncbi.nlm.nih.gov/books/NBK21811/ http://www.ncbi.nlm.nih.gov/books/NBK22025/ http://www.ncbi.nlm.nih.gov/books/NBK21996/ http://www.ncbi.nlm.nih.gov/books/NBK21989/ |
| 3/02 | No Class - Spring Break | ||
| 3/09 | Extensions of Mendel More on Dominance |
Gene Interaction From genes to phenotypes A diagnostic test for alleles Interactions between the alleles of one gene Gene interaction and modified dihybrid ratios Gene interaction in petal color of foxgloves Gene interaction in coat color in mammals Penetrance and expressivity Chi-square test | http://www.ncbi.nlm.nih.gov/books/NBK21966/ http://www.ncbi.nlm.nih.gov/books/NBK21921/ http://www.ncbi.nlm.nih.gov/books/NBK21920/ http://www.ncbi.nlm.nih.gov/books/NBK21850/ http://www.ncbi.nlm.nih.gov/books/NBK21774/ http://www.ncbi.nlm.nih.gov/books/NBK21804/ http://www.ncbi.nlm.nih.gov/books/NBK22090/ http://www.ncbi.nlm.nih.gov/books/NBK21907/ |
| 3/16 | Regulation of Gene Transcription | Regulation of
gene transcription Basic control circuits Discovery of the lac system: negative control Catabolite repression of the lac operon: positive control Positive and negative control Dual positive and negative control: the arabinose operon Metabolic pathways Additional examples of control: attenuation Transcription: an overview of gene regulation in eukaryotes Regulation of transcription factors Epigenetic inheritance | http://www.ncbi.nlm.nih.gov/books/NBK22020/ http://www.ncbi.nlm.nih.gov/books/NBK21821/ http://www.ncbi.nlm.nih.gov/books/NBK21954/ http://www.ncbi.nlm.nih.gov/books/NBK22065/ http://www.ncbi.nlm.nih.gov/books/NBK22091/ http://www.ncbi.nlm.nih.gov/books/NBK21849/ http://www.ncbi.nlm.nih.gov/books/NBK22095/ http://www.ncbi.nlm.nih.gov/books/NBK22103/ http://www.ncbi.nlm.nih.gov/books/NBK21780/ http://www.ncbi.nlm.nih.gov/books/NBK22024/ http://www.ncbi.nlm.nih.gov/books/NBK22029/ |
| 3/23 | Mutations | How DNA changes affect phenotype Somatic versus germinal mutation Mutant types Occurrence of mutations Selective systems Mutation induction Mutation and cancer Mutagens in genetic dissection Mutation breeding Mechanisms of Gene Mutation Molecular basis of gene mutations Spontaneous mutations Induced mutations Reversion mutations Relation betweeen mutagens and carcinogens Biological repair mechanisms Repair defects and human diseases | http://www.ncbi.nlm.nih.gov/books/NBK21955/ http://www.ncbi.nlm.nih.gov/books/NBK21894/ http://www.ncbi.nlm.nih.gov/books/NBK22011/ http://www.ncbi.nlm.nih.gov/books/NBK21833/ http://www.ncbi.nlm.nih.gov/books/NBK21857/ http://www.ncbi.nlm.nih.gov/books/NBK21796/ http://www.ncbi.nlm.nih.gov/books/NBK21809/ http://www.ncbi.nlm.nih.gov/books/NBK21888/ http://www.ncbi.nlm.nih.gov/books/NBK21969/ http://www.ncbi.nlm.nih.gov/books/NBK21933/ http://www.ncbi.nlm.nih.gov/books/NBK22074/ http://www.ncbi.nlm.nih.gov/books/NBK21897/ http://www.ncbi.nlm.nih.gov/books/NBK21936/ http://www.ncbi.nlm.nih.gov/books/NBK22101/ http://www.ncbi.nlm.nih.gov/books/NBK21788/ http://www.ncbi.nlm.nih.gov/books/NBK22004/ http://www.ncbi.nlm.nih.gov/books/NBK21794/ |
| 3/30 | Chromosomes Chromosomal Abnormalities | Topography of
the chromosome set Three-dimensional structure of chromosomes Sequence organization Chromosomal Mutation I: Changes in Chromosome Structure Origins of changes in chromosome structure Deletions Duplications Inversions Translocations Diagnosis of rearrangements by tetrad analysis Chromosome Mutations II: Changes in Chromosome Number Aberrant euploidy Aneuploidy Mechanisms of gene imbalance Chromosome mechanics in plant breeding |
http://www.ncbi.nlm.nih.gov/books/NBK22050/ http://www.ncbi.nlm.nih.gov/books/NBK22068/ http://www.ncbi.nlm.nih.gov/books/NBK21791/ http://www.ncbi.nlm.nih.gov/books/NBK21773/ http://www.ncbi.nlm.nih.gov/books/NBK21923/ http://www.ncbi.nlm.nih.gov/books/NBK21904/ http://www.ncbi.nlm.nih.gov/books/NBK21830/ http://www.ncbi.nlm.nih.gov/books/NBK22042/ http://www.ncbi.nlm.nih.gov/books/NBK21947/ http://www.ncbi.nlm.nih.gov/books/NBK21918/ http://www.ncbi.nlm.nih.gov/books/NBK21829/ http://www.ncbi.nlm.nih.gov/books/NBK22089/ http://www.ncbi.nlm.nih.gov/books/NBK21870/ http://www.ncbi.nlm.nih.gov/books/NBK21967/ http://www.ncbi.nlm.nih.gov/books/NBK21769/ |
| 4/06 | Genomes | Genomics Genomics: an overview Genome projects: practical considerations Structural genomics Functional genomics | http://www.ncbi.nlm.nih.gov/books/NBK21783/ http://www.ncbi.nlm.nih.gov/books/NBK21974/ http://www.ncbi.nlm.nih.gov/books/NBK21965/ http://www.ncbi.nlm.nih.gov/books/NBK21841/ http://www.ncbi.nlm.nih.gov/books/NBK22052/ |
| 4/13 | Transposable Elements | Transposable Genetic Elements Controlling elements in maize Bacterial insertion sequences Prokaryotic transposons Mechanism of transposition in prokaryotes Review of transposable elements in prokaryotes Molecular nature of transposable elements in eukaryotes Review of transposable elements in eukaryotes | http://www.ncbi.nlm.nih.gov/books/NBK21979/ http://www.ncbi.nlm.nih.gov/books/NBK21808/ http://www.ncbi.nlm.nih.gov/books/NBK21779/ http://www.ncbi.nlm.nih.gov/books/NBK21818/ http://www.ncbi.nlm.nih.gov/books/NBK21869/ http://www.ncbi.nlm.nih.gov/books/NBK21805/ http://www.ncbi.nlm.nih.gov/books/NBK21981/ http://www.ncbi.nlm.nih.gov/books/NBK21891/ |
| 4/20 | Cancer Genetics | Cancer as a Genetic Disease Cancer and the control of cell number: an overview Cell proliferation machinery Machinery for programmed cell death Controlling the cell-proliferation and death machinery Cancer: the genetics of aberrant cell control Cancer research in the genomic analysis era | http://www.ncbi.nlm.nih.gov/books/NBK22058/ http://www.ncbi.nlm.nih.gov/books/NBK22111/ http://www.ncbi.nlm.nih.gov/books/NBK21924/ http://www.ncbi.nlm.nih.gov/books/NBK21806/ http://www.ncbi.nlm.nih.gov/books/NBK21997/ http://www.ncbi.nlm.nih.gov/books/NBK21896/ http://www.ncbi.nlm.nih.gov/books/NBK22014/ |
| 4/27 | Turn in FINAL EXAM |